Emboldened by their discovery of a new form of Alzheimer’s, Drs. Francisco Lopera, Ken Kosik, and Lucia Madrigal embark on an audacious quest to defeat the disease, one that leads them across centuries and around the globe, from the Spanish conquest and the African slave trade to the frontlines of today’s most cutting-edge scientific research.  Desperate to prevail, the three scientists come face to face with the burdens of history, the power of genes, and their own limitations.